Abciximab package insert pdf

Iv administration of a single bolus doses of abciximab from 0. Abciximab or abcixifiban previously known as c7e3 fab, a glycoprotein iibiiia receptor antagonist manufactured by janssen biologics bv and distributed by eli lilly under the trade name reopro, is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent platelets from sticking together and causing thrombus formation within the. The glycoprotein iibiiia receptor inhibitors, abciximab, eptifibatide, and tirofiban, all have similar mechanisms of action to inhibit the platelet aggregation process. Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of abciximab in children with use in other age groups. Transfuse two 8packs of platelets as the patient is coming off pump. Monitor for symptoms such as hypoesthesia, hyperesthesia, paresthesia, discomfort, a burning sensation, neuropathic pain, or weakness. Highlights of prescribing information for psoriatic. Abciximab is used to lessen the chance of heart attack in people who need percutaneous coronary intervention pci, a procedure to open blocked arteries of the heart a heart attack may occur when a blood vessel in the heart is blocked by a blood clot. Because abciximab may increase the risk of bleeding, abciximab is contraindicated in the following clinical situations.

Abciximab abciximab binds to the glycoprotein gp iibiiia receptor of human platelets and inhibits platelet aggregation. Reopro fda prescribing information, side effects and uses. Trulicity is contraindicated in patients with a personal or family history of mtc or in patients with men 2. Abciximab definition of abciximab by medical dictionary. Protect the vials from light by storing in the original package until time of use. Remove the protective cap from the other end of the transfer. Stop continuous infusion of abciximab in patients with failed pcis. Adjunctive therapy during thrombolysis offlabel safety and efficacy not established. This medication should not be used if you have certain medical conditions. Abciximab blocks the sticking of platelets together and protects the arteries by reducing the formation of thrombus or blood clot. Abciximab intravenous route before using mayo clinic.

The chimeric 7e3 antibody is produced by continuous perfusion in mammalian cell culture. Orencia sc allows patients onceweekly selfinjection at home. Abciximab is an antiintegrin fab fragment of a human mouse chimeric monoclonal antibody with high affinity and a slow dissociation rate from the gpiibiiia platelet receptor mager et al 2003. Full prescribing information 1 indications and usage ocrevus is indicated for the treatment of. Taltz ixekizumab injection, for subcutaneous use initial u. Ceftazidime for injection, usp sagent pharmaceuticals. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for diamox sequels acetazolamide. In standard animal or human pharmacological tests, betaadrenoreceptor blocking activity of atenolol has been demonstrated by. Open the package containing the transfer device by peeling the paper label off the package. Pharmacodynamics and pharmacokinetics of abciximab. Highlights of prescribing information acute ischemic.

Abciximab fda orange book approved drug product list. Tirofiban is a nonpeptide reversible antagonist of the gpiibiiia receptor. Find patient medical information for abciximab intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Discontinue abciximab 48 hours before surgery if possible. Learn more about dosing, efficacy, safety and patient financial info for abraxane paclitaxel proteinbound particles for injectable suspension albuminbound. Abciximab binds to the glycoprotein gp iibiiia receptor of human platelets and inhibits platelet aggregation. Target aptt 50 to 70seconds if weight greaterthan or equal to 70kg, 5000unitbolus followed by infusion of unitsh. When abciximab is initiated 1824 hours prior to pci, maintain aptt between 6085 seconds. Abciximab is intended for use with aspirin and heparin and has been studied only in that setting, as described in clinical studies see package insert. Abciximab binds to the intact platelet gpiibiiia receptor, which is a member. Supporting documents older than three years albumin human related information. Abciximab is a chimeric monoclonal antibody that interferes with platelet aggregation by steric hindrance. This was a randomized, doubleblind, placebocontrolled, single and repeateddose 24hour study n101.

Integrilin should be given concomitantly with heparin dosed to achieve the following parameters. Like the ligandmimetic gpiibiiia inhibitors, abciximab causes thrombocytopenia within a. Before using this medicine, consult your doctor or pharmacist if you have. Easytoread drug name and dosage strength to aid in identifying the right product. Abciximab by injection national library of medicine. Remove the protective cap from one end of the transfer device and keeping the vial of swfi upright, insert the piercing pin vertically into the center of the stopper of the vial of swfi. If weight less than 70kg, 60unitskg bolus followed by infusion of 12unitskgh. Counsel patients regarding the potentialrisk for mtc with the use of trulicity and inform them of symptoms of thyroid tumors e. Heparin sodium injection, usp is a sterile, nonpyrogenic solution of a highly purified sodium salt of heparin, a high molecular weight polysaccharide derived from porcine intestinal mucosa or beef lung. Taltz is indicated for the treatment of adult patients with active ankylosing spondylitis.

To minimize the risk of bleeding with abciximab, it is important to use weightadjusted dosing of abciximab and lowdose weight adjusted doses of heparin, with adherence to stricter anticoagulation guidelines. Confirm the selection of the correct formulation and strength prior to administration of the drug. Leiden, the netherlands, a subsidiary of centocor, inc. Thus, abciximab is contraindicated in a numbers of conditions that create an increased risk of hemorrhage. The median bleeding time increased to over 30 minutes at both doses compared in human studies.

Patients received ofirmev 1 g with patientcontrolled analgesia pca morphine or placebo with pca morphine the morning following total hip or knee replacement surgery. Before using abciximab, tell your doctor or pharmacist if you are allergic to it. Scribd is the worlds largest social reading and publishing site. Bar codes included on the vial and carton for ease of scanning. Integrilin is indicated to decrease the rate of a combined endpoint of death or new myocardial infarction mi in patients with acs unstable angina uanonstelevation myocardial infarction nstemi, including patients who are to be managed medically and those undergoing percutaneous coronary intervention pci. Approved drug products containing abciximab listed in the fda orange book.

Abciximab inhibits platelet aggregation by preventing. Reopro abciximab for intravenous administration description. Relapsing forms of multiple sclerosis ms, to include clinically isolated syndrome, relapsingremitting disease, and active secondary progressive disease, in adults primary progressive ms, in adults 2 dosage and administration. Before heparinizing for cp bypass, draw act and give a titrated dose of heparin to obtain act of 400500 seconds. Abciximab can reduce platelet aggregation by more than 90%. For nonprescription products, read the label or package ingredients carefully. Reopro, abciximab dosing, indications, interactions. Abciximab binds irreversibly to the gpiibiiia receptors and blocks the binding of fibrinogen see fig. Abciximab injection reopro side effects, medical uses. Abciximab indications, dosage, side effects and precautions.